The Renin-Angiotensin-Aldosterone System — RAAS
Granulosa cells of the juxtaglomerular apparatus produce the enzyme renin. It proteolytically cleaves angiotensinogen into angiotensin I, which is hydrolyzed by the angiotensin-converting enzyme (ACE) to angiotensin (Ang) II. A rise in ANG II leads to the production of aldosterone in the cortex of the adrenal gland. The system serves to maintain blood pressure and can sense drops as small…