Pathophysiology
The Bartter syndrome If one of the transporters in the ascending limb of Henle’s loop fails due to a loss-of-function mutation, the so-called Bartter syndrome takes place. Thereby, resorption of Na+, Mg2+, Cl–and Ca2+ is disturbed. Although this can be partially or even completely reversed in later sections, it is associated with increased K+ and H+ secretion. Signs are Na+– and…